Proposal description
Make DASH a Household Name In Three Different $20 Billion Industries
We propose to run a scientific project promoting medical freedom that will shock 3 large and rapidly growing industries using the DASH blockchain. This project will leave DASH with a unique and charitable reputation in three fast growing and data intensive markets. This will test the DASH blockchain as a platform that could see a tripling of its transaction volume if others see the value in this approach.
• Make history in the Cannabis industry
• Make history in the Scientific Publishing market
• Make history in the Genomics industry
$71K (160 DASH): 30 DASH/month. 5 Months
*This is an expansion of a very popular and successful proposal (1058:105 Yes:No)
https://www.dashcentral.org/p/MedicinalGenomics
How?
Sequence a controversial Cannabis genome and publish it using a novel crypto-incentivized, crypto-recorded peer review process that will cut out the $25B Scientific publishing market.
Sequence the genome with the latest Next Generation Sequencing tools to encourage this 20% compound annual growth rate (CAGR) market to take notice of crypto-sponsored and crypto-published genomics.
Publish the genome of a cannabis plant that is the center point of overly broad and controversial cannabis patents to assist in challenging these detrimental IP land grabs on medicinal plants. Publish this on the DASH Blockchain to set a new standard for a $25B/year peer review platform.
If the idea of crypto-incentivized, crypto-recorded peer review catches on, DASH could see a tripling of its transaction volume. The scientific publishing market is a $25B market. There are 2.5M scientific publications every year costing an average of $3k per submission in publication costs and the submission frequency is doubling every 9 years. This $7.5B review market is prime for cutting out the expensive middleman as it is cracking at the seams under ancient Gutenberg incentive models. The internet has made the cost of publication near zero and DASH has already solved the censorship resistance problem, consensus, trust and permanence problems as well. The journals are no longer needed and the market is sprung to remove their parasitic copyright enabled grasp on scientific data and truth dissemination.
Today, reviewers are usually anonymous and free. They have the accuracy of a twitter troll. Journals copyright the scientific work themselves and charge the researchers or the public to access it later, even if the work is publically funded. Half of the papers published can’t be reproduced and the most prestigious journals have the highest retraction rates. The incentives are broken. Why pay the journals for such poor results? This is not how science should function. Researchers should be able to pay reviewers directly. Cut the copyright out and create a market for good and bad review. These reviews and manuscripts can be published on the DASH blockchain. With the addition of a price signal to the cost of Peer Review, all of the historical misalignments change. Good reviewers will build reputation and demand higher prices. Reviewers simply “rubber stamping” their friends work will be discounted with transparent non-anonymous review. Public and immutable reputation systems change the game theoretics and align incentives for accuracy.
With this simple change, new tiers of review can evolve. Platinum, gold and bronze review will speciate to afford a market where people can pay to have the work partially or fully reproduced. DASH enables this market as a financial vehicle for the reputation and payment system. It enables the notarization engine for the peer review and DASH drive uniquely delivers a distributed drive system for critical scientific data.
There is a strong argument for scientific data to be on a blockchain. The current scientific databasing model often reflects a tragedy of the commons where we experience a 17% annual data decay despite large government subsidies to manage these databases. Blockchains create a monetary alignment delivering 0% decay per year. In addition to data decay, the databases lack pricing signals and thus are very cumbersome to use as they are not designed with customer pricing signals guiding the feature releases. The process to submit data to NCBI often requires a PhD-day and the uptime of these databases are frequently threatened by budget ceiling debates. The import friction seen in these socialized databases translates into key data from manuscripts being omitted from the submission process and rusting on unreliable servers in the form of “supplemental data”. Keynesian backed databases are not a reliable store for the scientific record.
https://www.cell.com/current-biology/fulltext/S0960-9822(13)01400-0
https://peerj.com/blog/post/115284879109/authors-can-now-directly-submit-to-peerj-from-biorxiv/
http://www.cdnsciencepub.com/blog/21st-century-science-overload.aspx
If the $7.5B peer reviewed publications get converted to Crypto-bounties and paid in DASH to 2-3 reviewers per journal article, this alone could triple the transaction volume of DASH.
2.5M publications per year = ~7,000 publications/day * 2-3 reviewers/manuscript to be bountied in DASH. This delivers an estimated $5B-$7B in velocity of DASH. This does not include the notarizations for the review process or the pre-print server market.
The growth of the pre-print servers are now hosting 1200 new manuscripts per month and would likely require 100 notarizations per article to include the manuscript, figures, and all communications between the authors and editors. If DASH were to capture the whole market (unlikely with this proposal alone), it would entail hashing 12K-24K transactions per month. It is important to underscore that this proposal is a proof of concept. Getting BioRXIV, F1000 and PLoS to adopt such an approach is more likely to happen if we demonstrate it can be done.
The remaining $17.5B in the scientific publishing market is advertisements and subscription fees. Once DASH has the eyeballs for the scientific content and trust delivery platform, both of these markets can be reached with DASH currency and DASH drive.
The DASH investment in alternative media to promote truth in our media is greatly augmented if we are concurrently seen as a beacon of scientific truth.
DASH already has large investments in the Cannabis industry with Alt36, Kannapedia.net and CannMed funding. Sequencing the genome of the most ominous patent issuance will make DASH a household name in the Cannabis Industry.
The genomics market is a quickly emerging personalized medicine market. It changes the medical paradigm of one-sized fits all drugs and herd medicine to one that is more individualistic. Political structures prevent cannabis genomics from being funded. This maket is very data and CPU intensive and various Genomic Blockchain companies are getting funded to use ETH (Nebula, Shivom, LunaDNA, Zenome, Encrypgen). This is the right time to get those companies thinking about the more appropriate architecture of DASH for this $20B market.
The pre-proposal project is already capturing headlines at Dash Force News, The Cannabis Connection, The Tatiana Show, and the Future Tech Podcast.
• https://www.youtube.com/watch?v=pAGwhueEub8
• April 27th - http://kscocom/shows/43015-the-cannabis-connection
• https://www.futuretechpodcast.com/podcasts/kevin-mckernan-medicinal-genomics-pioneering-study-cannabis-genetics-dna-based-measurement-microbial-risks/
• https://www.dashforcenews.com/dash-gaining-traction-in-cannabis-industry-proposal-seeks-funding-for-genome-research/
Future exposure is planned at The Broad Institute geXc conference, The society for in-vitro biology, and CannMed 2018
• https://www.gexcsymposia.com.
• https://sivb.org/meetings/home/scientific-program-3.html
• https://Cannmedevents.com
TECHNICAL DETAILS
https://www.medicinalgenomics.com/wp-content/uploads/2018/05/disrupt-three-20b-industries-with-dash_5_7_2018_tech.docx
We propose to run a scientific project promoting medical freedom that will shock 3 large and rapidly growing industries using the DASH blockchain. This project will leave DASH with a unique and charitable reputation in three fast growing and data intensive markets. This will test the DASH blockchain as a platform that could see a tripling of its transaction volume if others see the value in this approach.
• Make history in the Cannabis industry
• Make history in the Scientific Publishing market
• Make history in the Genomics industry
$71K (160 DASH): 30 DASH/month. 5 Months
*This is an expansion of a very popular and successful proposal (1058:105 Yes:No)
https://www.dashcentral.org/p/MedicinalGenomics
How?
Sequence a controversial Cannabis genome and publish it using a novel crypto-incentivized, crypto-recorded peer review process that will cut out the $25B Scientific publishing market.
Sequence the genome with the latest Next Generation Sequencing tools to encourage this 20% compound annual growth rate (CAGR) market to take notice of crypto-sponsored and crypto-published genomics.
Publish the genome of a cannabis plant that is the center point of overly broad and controversial cannabis patents to assist in challenging these detrimental IP land grabs on medicinal plants. Publish this on the DASH Blockchain to set a new standard for a $25B/year peer review platform.
If the idea of crypto-incentivized, crypto-recorded peer review catches on, DASH could see a tripling of its transaction volume. The scientific publishing market is a $25B market. There are 2.5M scientific publications every year costing an average of $3k per submission in publication costs and the submission frequency is doubling every 9 years. This $7.5B review market is prime for cutting out the expensive middleman as it is cracking at the seams under ancient Gutenberg incentive models. The internet has made the cost of publication near zero and DASH has already solved the censorship resistance problem, consensus, trust and permanence problems as well. The journals are no longer needed and the market is sprung to remove their parasitic copyright enabled grasp on scientific data and truth dissemination.
Today, reviewers are usually anonymous and free. They have the accuracy of a twitter troll. Journals copyright the scientific work themselves and charge the researchers or the public to access it later, even if the work is publically funded. Half of the papers published can’t be reproduced and the most prestigious journals have the highest retraction rates. The incentives are broken. Why pay the journals for such poor results? This is not how science should function. Researchers should be able to pay reviewers directly. Cut the copyright out and create a market for good and bad review. These reviews and manuscripts can be published on the DASH blockchain. With the addition of a price signal to the cost of Peer Review, all of the historical misalignments change. Good reviewers will build reputation and demand higher prices. Reviewers simply “rubber stamping” their friends work will be discounted with transparent non-anonymous review. Public and immutable reputation systems change the game theoretics and align incentives for accuracy.
With this simple change, new tiers of review can evolve. Platinum, gold and bronze review will speciate to afford a market where people can pay to have the work partially or fully reproduced. DASH enables this market as a financial vehicle for the reputation and payment system. It enables the notarization engine for the peer review and DASH drive uniquely delivers a distributed drive system for critical scientific data.
There is a strong argument for scientific data to be on a blockchain. The current scientific databasing model often reflects a tragedy of the commons where we experience a 17% annual data decay despite large government subsidies to manage these databases. Blockchains create a monetary alignment delivering 0% decay per year. In addition to data decay, the databases lack pricing signals and thus are very cumbersome to use as they are not designed with customer pricing signals guiding the feature releases. The process to submit data to NCBI often requires a PhD-day and the uptime of these databases are frequently threatened by budget ceiling debates. The import friction seen in these socialized databases translates into key data from manuscripts being omitted from the submission process and rusting on unreliable servers in the form of “supplemental data”. Keynesian backed databases are not a reliable store for the scientific record.
https://www.cell.com/current-biology/fulltext/S0960-9822(13)01400-0
https://peerj.com/blog/post/115284879109/authors-can-now-directly-submit-to-peerj-from-biorxiv/
http://www.cdnsciencepub.com/blog/21st-century-science-overload.aspx
If the $7.5B peer reviewed publications get converted to Crypto-bounties and paid in DASH to 2-3 reviewers per journal article, this alone could triple the transaction volume of DASH.
2.5M publications per year = ~7,000 publications/day * 2-3 reviewers/manuscript to be bountied in DASH. This delivers an estimated $5B-$7B in velocity of DASH. This does not include the notarizations for the review process or the pre-print server market.
The growth of the pre-print servers are now hosting 1200 new manuscripts per month and would likely require 100 notarizations per article to include the manuscript, figures, and all communications between the authors and editors. If DASH were to capture the whole market (unlikely with this proposal alone), it would entail hashing 12K-24K transactions per month. It is important to underscore that this proposal is a proof of concept. Getting BioRXIV, F1000 and PLoS to adopt such an approach is more likely to happen if we demonstrate it can be done.
The remaining $17.5B in the scientific publishing market is advertisements and subscription fees. Once DASH has the eyeballs for the scientific content and trust delivery platform, both of these markets can be reached with DASH currency and DASH drive.
The DASH investment in alternative media to promote truth in our media is greatly augmented if we are concurrently seen as a beacon of scientific truth.
DASH already has large investments in the Cannabis industry with Alt36, Kannapedia.net and CannMed funding. Sequencing the genome of the most ominous patent issuance will make DASH a household name in the Cannabis Industry.
The genomics market is a quickly emerging personalized medicine market. It changes the medical paradigm of one-sized fits all drugs and herd medicine to one that is more individualistic. Political structures prevent cannabis genomics from being funded. This maket is very data and CPU intensive and various Genomic Blockchain companies are getting funded to use ETH (Nebula, Shivom, LunaDNA, Zenome, Encrypgen). This is the right time to get those companies thinking about the more appropriate architecture of DASH for this $20B market.
The pre-proposal project is already capturing headlines at Dash Force News, The Cannabis Connection, The Tatiana Show, and the Future Tech Podcast.
• https://www.youtube.com/watch?v=pAGwhueEub8
• April 27th - http://kscocom/shows/43015-the-cannabis-connection
• https://www.futuretechpodcast.com/podcasts/kevin-mckernan-medicinal-genomics-pioneering-study-cannabis-genetics-dna-based-measurement-microbial-risks/
• https://www.dashforcenews.com/dash-gaining-traction-in-cannabis-industry-proposal-seeks-funding-for-genome-research/
Future exposure is planned at The Broad Institute geXc conference, The society for in-vitro biology, and CannMed 2018
• https://www.gexcsymposia.com.
• https://sivb.org/meetings/home/scientific-program-3.html
• https://Cannmedevents.com
TECHNICAL DETAILS
https://www.medicinalgenomics.com/wp-content/uploads/2018/05/disrupt-three-20b-industries-with-dash_5_7_2018_tech.docx
Show full description ...
Discussion: Should we fund this proposal?
Submit comment
http://bigbudsmag.com/will-jamaican-lion-save-the-cannabis-industry-from-patent-trolls/
I think the Peer review side of this proposal was the hardest to explain as its so foreign to many people. Anyone with an Austrian viewpoint would see the whole thing as the expected outcome with poorly aligned incentives. I'm very excited to learn that Dash Labs is now taking this problem on as one of their main goals.
https://www.dashforcenews.com/dash-labs-exclusive-update-interview-with-tito-rios-on-data-collection-protocol/
We are off to CannMed. Thank you DASH!
haplotigs:
====================
Contigs | withNs | withoutNs
====================
#Seqs | 5,389
Min | 177
1st Qu.| 38,060
Median | 54,249
Mean | 68,560
3rd Qu.| 78,021
Max | 1,586,457
Total | 369,469,991
n50 | 79,041
n90 | 39,471
n95 | 32,292
primaries:
====================
Contigs | withNs | withoutNs
====================
#Seqs | 574
Min | 31,932
1st Qu.| 300,322
Median | 903,374
Mean | 1,865,698
3rd Qu.| 2,203,352
Max | 32,540,838
Total | 1,070,911,180
n50 | 3,793,934
n90 | 916,761
n95 | 561,728
https://osf.io/7d968/?file=5bbf004495e98a00187863e1
We have initiated the crypto review
Latest assembly can be downloaded from here-
https://mega.nz/#!RZAAQY6B!BlG2qvB7-xk-VIYaJOTQ-SSEAK0diJ64gTRMW85_5Ls
https://www.newsmunchies.com/2018/09/cannmed-2018-to-showcase-greatest-minds-in-cannabis-research/
https://www.futuretechpodcast.com/podcasts/kevin-mckernan-cso-medicinal-genomics-solutions-safe-quality-cannabis/
I just attended the Cannabis Science Conference in Portland and this is still the record genome out there. Sunrise genetics is a close second but their data isn’t public. Has been held private since January.
Had they been more open, the work Phylos presented trying to tease apart the Synthase genes with HMM models would have been unnecessary as you can clearly see this clustering now with the Jamaican Lion Assembly.
It was very refreshing to see Steep Hill soak up the data and tear into. Keith Allen presented an excellent poster on Cannabinoid diversity using this reference.
Keith was the former Head of Bioinformatics for Syngenta
solarguy
Make DASH a Household Name In Three Different $20 Billion Industries by KevinMcKernan
https://dashwatch.org/files/1535394047855.pdf
We now have a Polished Assembly.
https://www.medicinalgenomics.com/dash-powered-genomics/
N50 is the standard metric used to quality check genomic assemblies. It means half of the bases in the assembly are in chunks of X size or bigger. An N50 of 665Kb is 665,000 bases long.
A program call Quast is commonly used to measure the quality of an assembly and generates these statistics.
BUSCO is a tool used to look for a minimum gene set that is conserved through most plant species.
There are 1440 conserved orthologous genes in Arabidopsis and other plant species.
The current BUSCO results demonstrate this assembly has 92.9% of the orthologs from Arabidopsis. This is very good.
DASH blockchain records-
filename: jamaicanlion_falcon_unzip_arrow_haplotigs_160818.fasta.gz,
digest: db9216e4e1e1b72b1540ab7d9ae76462ebaaed5710e32e39363bfc9587bc73c0,
transaction id: 73012ba6ef8b9af67a6b9e36974bd38c37c9c1d6e6ecab873e657b79f1da17fa
filename: jamaicanlion_falcon_unzip_arrow_primary_160818.fasta.gz,
digest: 21440180f4e06755c701fdc3f863d9d3edf5fdbea721ca122bce84ee672061dd,
transaction id: 0653c54153493f2b8d6c1cee66c869454c3ff904aa18ed18f92f608ad7383a77
They are on the IPFS
Assemblies are now Public on the Interplanetary File System (IPFS)
ipfs add jamaicanlion_falcon_unzip_arrow_primary_160818.fasta
added QmWKQeaKqxREq8yuMeJTh7ZeXc9Kmn2PQnc1MuwrscjJ6V jamaicanlion_falcon_unzip_arrow_primary_160818.fasta
ipfs add jamaicanlion_falcon_unzip_arrow_haplotigs_160818.fasta
added QmebrttnJtKUC5NUYJMpEcApukvx2zC2142CypQXy8D8zo jamaicanlion_falcon_unzip_arrow_haplotigs_160818.fasta
IPFS get Hash should download the respective files. You need software from IPFS.io to pull these down.
They are on Mega.nz
https://mega.nz/#!JMYlBapT!Ygq4bJruNAjB0GBUUvhVOdw8sT2ee2LgFQeJ9eDvVa0
https://mega.nz/#!BZI2AQKB!l6wiPCYaagkLiGrnG4x87Vzl1cYi6shrJfXPXfrsRW8
They are on AWS
http://mgcdata.s3.amazonaws.com/reference/jamaicanlion_falcon_unzip_arrow_primary_160818.fasta.gz
http://mgcdata.s3.amazonaws.com/reference/jamaicanlion_falcon_unzip_arrow_haplotigs_160818.fasta.gz
https://growupconference.com/conference/all-speakers
Protest from Cannabis Canada Association-
http://brevets-patents.ic.gc.ca/opic-cipo/cpd/eng/patent/2911168/images.html?page=1&frenchDocType=Poursuite-Amendment&englishDocType=Prosecution-Amendment&modificationDate=20171225&scale=25&rotation=0&type=&objectName=A1001001A18G27B04404I85157&numPages=9&query=*&start=301&num=50
Response from "inventors"
http://brevets-patents.ic.gc.ca/opic-cipo/cpd/eng/patent/2911168/images.html?page=7&frenchDocType=Poursuite-Amendment&englishDocType=Prosecution-Amendment&modificationDate=20171231&scale=25&rotation=0&type=&objectName=A1001001A18H02B04500H34625&numPages=13&query=*&start=301&num=50
Here is the complete file wrapper-
http://brevets-patents.ic.gc.ca/opic-cipo/cpd/eng/patent/2911168/summary.html?query=*&start=301&num=50&type=
The patents did issue with reduced scope in Canada on August 14th, 2018 but the examiner has yet to see this projects data regarding the 2007 date of Jamaican Lion.
https://www.freedomsphoenix.com/Media/Media-Files/001-0810121943-2018-08-10-Hour-2-Kevin-McKernan---Cannabis-Genome-on-DASH-Blockchian.mp3
Many accolades to the DASH community for making this happen.
https://www.medicinalgenomics.com/crypto-funded-public-genomics/
A very key one is the Hash for the first DNA assembly that is now live.
SHA256: 1f6dc3d2c1f69428e67b8f9b7712a94224467cd5744b481ffb5a41f8d12a3cbe
TransactionID: 9622725bc9093625c24bac7574b96196fb579dc49f9803b70dbae18f337f731c
https://www.dashforcenews.com/dash-and-medicinal-genomics-beats-dna-sequencing-record-of-human-genome-project/
https://www.medicinalgenomics.com/dash-powered-genomics/
Here is the blockchain information for the gz file:
filename: JamaicanLion_FALCON_primary_contigs_unpolished.fa.gz
SHA256: 1f6dc3d2c1f69428e67b8f9b7712a94224467cd5744b481ffb5a41f8d12a3cbe
TransactionID: 9622725bc9093625c24bac7574b96196fb579dc49f9803b70dbae18f337f731c
JamaicanLion.fa
SHA256 digest: 51975e1ed51748aa5f13d4fe755d65e30c8cb06f6273b8439c1519fb01727280
Transaction ID: 83b1c54c7cbaf0f6446912060c1b0689388bbd1b4b11750d30256e4681ce3725
The Cannabis Reference just assembled is more contiguous than the Human Genome was in 2001 (N50s over 600kb).
This is a huge step forward for the Cannabis genome.
Make DASH a Household Name In Three Different $20 Billion Industries by KevinMcKernan
https://dashwatch.org/files/1532760578215.pdf
It is in fact the most contiguous cannabis assembly to date by a long shot.
It is also revealing that the genome is over 1 billion bases as we suspected.
For the first time in human history we have a picture of THCA Synthase and CBDA Synthase on the same contiguous stretch of sequence. They are closer than others have predicted.
25 percent of the genome is already phased using FALCON unzip.
Each chromosome is in ~140 pieces but more polishing work is required to turn this into 1-10 pieces per chromosome.
This is remarkably fast progress and much is owed to the DASH network for making this bet.
It has made many people want to contribute to the project based on its unique funding model.
We are getting more done despite the currency decline because people see the cause and are thrilled Dash Crypto
has saved the day here.
Once we have assembly data downloaded and verified we will work on posting it. The data vendor wants to finish the polishing step before putting data public.
This may take a few weeks with summer vacations etc.
solarguy
https://www.bostonglobe.com/business/2018/07/23/this-woburn-company-ready-test-pot/iORH0cWB5AdRW4SlZDQiOJ/story.html?s_campaign=8315
These folks are paying attention to crypto and are buying DNA sequencers.
Going to be a great conference.
What does 91Gb of sequence data mean?
Assuming a 1Gb genome, we have 91X coverage. This means each base in the genome should be read 91 times. This reduces error. At least 50X coverage is required for de novo assembly of genomes with this platform. Of the 91X coverage sequence data, 50% of the bases are in reads longer than 32,000bp (32Kb N50s). This "should" be sufficient to drastically improve the reference genome.
This is now moving into DNA assembly which requires over 512Gb of RAM on hundreds of processors. This is an All against All or N^2 problem with 4.8million reads or 23 Trillion read alignments. It can take weeks to complete on the High Performance computers. There is now a read length histogram on the bottom of the project page. https://www.medicinalgenomics.com/crypto-funded-public-genomics/
Make DASH a Household Name In Three Different $20 Billion Industries by KevinMcKernan
https://dashwatch.org/files/1530055581717.pdf
Dash Watch June 26th 2018 Report on
Cannabis Genomic Blockchain on DASH and CannMed 2018 Partnership by KevinMcKernan
https://dashwatch.org/files/1530055652163.pdf
Tikun Olam is the largest grow in Israel.
http://www.tikunolam.com
Papa and Barkley's is a speciality Cannabis brand in California and was just written up in Forbes. I had meeting with Adam Grossman in Marblehead last weekend.
There are 3 more sponsors that agreed to terms but we are awaiting checks in the mail. Ticket sales are beginning to climb.
https://www.forbes.com/forbes/welcome/?toURL=https://www.forbes.com/sites/julieweed/2018/06/22/californias-papa-barkley-cannabis-company-grows-with-teamwork/&refURL=https://www.google.com/&referrer=https://www.google.com/
https://www.pacb.com/products-and-services/pacbio-systems/sequel/
Here is a robotic DNA isolation performed on 12 samples from the same plant.
https://d.tube/#!/v/lariat/n6eixexj
https://www.youtube.com/watch?v=F98fsCamVQA
solarguy
Made a few quick slides to illustrate it.
https://mega.nz/#!RR40Fb7A!ltbWuRwyFcLUVtTgv_f4-pnsm14nHcuKWFDmijmBR-c
Great cast.
https://itunes.apple.com/us/podcast/shaping-fire/id1170242921?mt=2#episodeGuid=http%3A%2F%2Fwww.blubrry.com%2Fshapingfire%2F34767958%2F
These projects are run on Illumina sequencers. These sequencers only produce short reads but are the cheapest way to get a fingerprint of a plant today.
The first one went live yesterday and was etched into DASH.
Once we have a better referende Genome from this DASH project it will greatly enhance the interpretation of that data.
We’ve kept moving in the Lab.
Yesterday we had robotics purifying DNA from Jamaican Lion stems. It’s hard to get DNA out of stems. Requires steel ball bearings and robotic vortexing but it’s the only legal way to move hemp samples in the states according to Hemp Industry Association vs. DEA.
https://www.medicinalgenomics.com/crypto-funded-public-genomics/
https://youtu.be/_QLs-8el9A8
http://www.cannmedevents.com/join-the-growing-list-of-industry-leaders-participating-in-cannmed-2018/
My CV is buried at the bottom of the proposal for anyone who wants more detail on my history.
https://mega.nz/#!4V5FTKSA!i5wYrDI9TTXXjMMjyZ8ZirWCdjBw5susPg8TdAeepTQ
We should have a Kannapedia.net report this week.
The Lab Log can be seen below.
https://www.medicinalgenomics.com/crypto-funded-public-genomics/
solarguy
https://www.theguardian.com/science/2012/apr/24/harvard-university-journal-publishers-prices
solarguy
Once Trump legalizes, the window to capture the cannabis market with crypto shrinks. Once on Crypto, I doubt it will go back.
http://thehill.com/blogs/blog-briefing-room/news/391371-trump-says-hell-likely-support-bill-letting-states-set-their
California is talking about doing this independent of Trump.
https://www.americanbanker.com/news/pot-banking-bill-advances-in-california
I am quit certain most people will move back to fiat as soon as possible, once it's legally possible.
This cannabis markt is may very well turn into one giant sink hole for dash.
I was also on Ernest Hancock show today discussing how this method of scientific publishing encourages researchers to hash and stash their results real time like a data rich twitter feed. This brings the journal of negative results into public view and greatly accelerates the sharing of scientific data. Traditional publications encourage data hoarding for years or risk getting scooped in publication. This model reverses those incentives as the gatekeeper of publication is removed.
We have already hashed two datasets this week and are expecting to Hash many more on Sunday/Monday as the Illumina sequencing matures.
1)https://www.medicinalgenomics.com/wp-content/uploads/2018/05/e7ef91922ea6cdc87fe9b557791a9e8d643d2c5a9e121fb7f2bb1f4d95409b13.pdf
2)https://www.medicinalgenomics.com/wp-content/uploads/2018/05/8cecc2636272ecc2630e565c389d34a8a82d75930c2d3e93342e6f7179373beb.pdf
We are 4 days into funding and we have
1)Screened dozens of plants for Type II genetic status
2)Performed multiple DNA isolations for 2 different sequencing platforms (Pacific Biosciences and Illumina).
3)Organized the decentralization of the plant with growers. Asked growers to make multiple clones and distributed them to other growers asking each to clone it and give it to 4 other legal growers so a perpetual clone stock of the plant remains alive as a public resource.
4)Loaded an Illumina Miseq to screen the genome before we perform the expensive Pacific Bioscience sequencing.
The project is being live streamed with daily lab updates at-
https://www.medicinalgenomics.com/crypto-funded-public-genomics/
solarguy
Walter
https://www.medicinalgenomics.com/crypto-funded-public-genomics/
The first funds we received on Sunday and we hit the ground running today screening many candidate Type II plants. We have identified the Plant to be sequenced and put a plan in place for the grower to clone the plant out and keep many cuts of it alive throughout the course of the project. Grower is preferring to remain anonymous at this point in time but may put their name on the project once they see it mature. If folks know of any trustworthy Tissue Culture Labs in the Mass area, that would be another great way to ensure there is archive of the tissue researchers can obtain.
A real time Lab Notebook is being kept at this site: https://www.medicinalgenomics.com/crypto-funded-public-genomics/
15 more votes folks. What do I have to do? Foot massages at the next big conference? Wax your car?
Whatever it takes....
solarguy
We are excited to have Chuck Williams speaking about DASH!
http://www.cannmedevents.com/schedule/?utm_campaign=CannMed2018&utm_source=hs_email&utm_medium=email&utm_content=63329424&_hsenc=p2ANqtz-_86_9O6LmoqOkUJmM5uSjyd6L6yQlw_n2V97YqPzL9PmMpDjXA7-8meieJKqbzEFo_sj9wGu55Z17FoUKA2_bRHDkyBTpCERlrCplHR-SxVWbqM9s&_hsmi=63330069
We can make it much harder for Monsanto and Bayer and the Food and Drug Administration to turn medical cannabis into a near monopoly with overly broad patents.
And, we can turn heads in the cannabis genetics research industry. If this test case of how to fund great science goes well, we could fund other research. This will make more economic sense when Dash can become partners and reap economic benefits directly. But that's on the way.
Each of those three projects (by itself) is is worth the asking price. And hey, it doesn't hurt to make the world a better place as a nice bonus. But don't worry, the David vs Goliath angle will make for fantastic marketing for years to come.
Kevin is the real deal. Please vote yes,
solarguy
Chuck Williams will be speaking in DASHs progress.
http://www.cannmedevents.com/schedule/?utm_campaign=CannMed2018&utm_source=hs_email&utm_medium=email&utm_content=63329424&_hsenc=p2ANqtz-_86_9O6LmoqOkUJmM5uSjyd6L6yQlw_n2V97YqPzL9PmMpDjXA7-8meieJKqbzEFo_sj9wGu55Z17FoUKA2_bRHDkyBTpCERlrCplHR-SxVWbqM9s&_hsmi=63330069
Yes, I have a long history of being awarded many patents in my younger life. I have found that investment to be questionable. What if we put that money back into R&D to go faster and not dig legal moats? These legal moats often distract the R&D team writing patents. Patent law changes every other year adding costs and uncertainty. Patents can take 3-5 years to issue and many technologies are in the grave before the patent issues. I also question the ethics of IP. Stephan Kinsellas work best summarizes how I feel today which respects defensive IP but questions offensive IP. I feel the USPTO is centralized, error prone but cant be ignored or you'll find your work being patented after you.
To this end, here are the claims to one of the CIPs (Continuation in Part) Cannabis Patents.
Note the use the term clone. That is key genetic language.
Note the use of the term Bt:Bd allele. That is key genetic language.
Not the broad nature of the claim. Anything more than 1.5% Cannabinoids is theirs. The market is filled with 15%-20% cannabinoid plants. If you cant breed this, you are a dunce. If you cant get more than 1% terps, you are less of a dunce as above but this isn't novel.
A ratio of 1.4 THC:CBD. This isn't novel. Its arguably the natural state of the plant but the USPTO is too ignorant on the topic to examine this and they have very little motivation for accuracy. They make money on re-examinations.
1. A cannabis plant, or an asexual clone of said cannabis plant, or a plant part, tissue, or cell thereof, which produces a female inflorescence, said inflorescence comprising: wherein the contents of THC and CBD comprise acidic and decarboxylated cannabinoids as measured by high performance liquid chromatography (HPLC) and calculated based on dry weight of the inflorescence; wherein the terpene oil content is the additive content of the terpenes in the inflorescence's terpene profile; wherein the terpene profile consists of terpinolene, alpha phellandrene, beta ocimene, carene, limonene, gamma terpinene, alpha pinene, alpha terpinene, beta pinene, fenchol, camphene, alpha terpineol, alpha humulene, beta caryophyllene, linalool, caryophyllene oxide, and myrcene; and wherein the terpene contents are measured by gas chromatography-flame ionization detection (GC-FID) and are calculated based on dry weight of the inflorescence; wherein a representative sample of seed capable of producing said plants has been deposited under NCIMB Nos. 42248, 42249, and wherein cellular cultures representative of said plants are deposited under Bigelow NCMA Nos. PATENT201611001, PATENT201609001, and PATENT201612001.
a) at least one BT allele, and at least one BD allele;
b) cannabidiol (CBD) cannabinoid content of at least 1.5% by weight;
c) a tetrahydrocannabinol (THC) cannabinoid content such that the THC:CBD content ratio is greater than 1.4; and
d) a terpene oil content greater than about 1.0% by weight;
It is a large download (3Gb). Working on the size now.
https://spaces.hightail.com/space/LM6jJSmLdV
Airdropped last week with June distros.
Has much of the same language regarding incentives but missing the cannabis genomics appeal.
https://labledger.net/
This would honestly make me consider buying up more DASH to become an MNO as the currency would have multiple valuation models. There are the transaction velocity models often written about by Chris Burniske. These would have to be updated to place NPVs on the equity held by the DASH MNOs. Handling the Phantom income taxes that often hit shareholders of small start ups will be interesting but assuming the lawyers figure this all out, it does make DASH a unique staking coin.
Similar to this, if we capture a portion of the annual $20 B market for publishing scientific data, DASH valuation becomes anchored and augmented in humankinds perpetual demand for scientific discovery. Its one thing to have a currency backed by subjectively valued metals. It is an entirely different matter to have a currency that is anchored in entrepreneurship and scientific discovery.
This reminds me of IOHK and Charles desire to get more rigorous peer review in Crypto. I think its more interesting to make crypto redefine peer review than have the old school peer review process "bless" crypto.
Looking forward to making this happen.
Cannabis Genomic Blockchain on DASH and CannMed 2018 Partnership by KevinMcKernan
https://dashwatch.org/files/1527512922890.pdf
More DASH Coverage.
https://thefreethoughtproject.com/scientists-blockchain-cannabis-patents/
We are on track even with a currency a decay.
Instead of asking for a Fiat guarantee, we have decided to hustle and bring in more lower level sponsors for the conference. We have done this while still leaving DASH as the exclusive Partnership Sponsorship level.
We are an adaptive startup.
You will notice that this project still enjoys the highest %vote participation for all active projects on the DASH vote tracker. We can repeat this success with this project.
https://dashvotetracker.com/index.html
https://dashwatch.org/files/1527512922890.pdf
Lets get the DASH name permanently etched into the Cannabis history record!
http://www.kannapedia.net/cannabis-phylotree/
http://www.kannapedia.net/strains/RSP10085
http://www.kannapedia.net/strains/RSP10105
http://www.kannapedia.net/strains/RSP10105
http://www.kannapedia.net/strains/RSP10243
http://www.kannapedia.net/strains/RSP10460
http://www.kannapedia.net/strains/RSP10603
http://www.kannapedia.net/strains/RSP10628
http://www.kannapedia.net/strains/RSP10632
http://www.kannapedia.net/strains/RSP10635
http://www.kannapedia.net/strains/RSP10641
http://www.kannapedia.net/strains/RSP10649
http://www.kannapedia.net/strains/RSP10652
http://www.kannapedia.net/strains/RSP10653
http://www.kannapedia.net/strains/RSP10655
http://www.kannapedia.net/strains/RSP10658
http://www.kannapedia.net/strains/RSP10659
http://www.kannapedia.net/strains/RSP10661
http://www.kannapedia.net/strains/RSP10664
http://www.kannapedia.net/strains/RSP10665
http://www.kannapedia.net/strains/RSP10667
http://www.kannapedia.net/strains/RSP10668
http://www.kannapedia.net/strains/RSP10670
http://www.kannapedia.net/strains/RSP10671
http://www.kannapedia.net/strains/RSP10680
http://www.kannapedia.net/strains/RSP10684
http://www.kannapedia.net/strains/RSP10698
http://www.kannapedia.net/strains/RSP10755
http://www.kannapedia.net/strains/RSP10763
http://www.kannapedia.net/strains/RSP10837
http://www.kannapedia.net/strains/RSP10976
http://www.kannapedia.net/strains/RSP10977
http://www.kannapedia.net/strains/RSP10978
http://www.kannapedia.net/strains/RSP10979
http://www.kannapedia.net/strains/RSP10980
http://www.kannapedia.net/strains/RSP10981
http://www.kannapedia.net/strains/RSP10982
http://www.kannapedia.net/strains/RSP10983
http://www.kannapedia.net/strains/RSP10988
http://www.kannapedia.net/strains/RSP10989
http://www.kannapedia.net/strains/RSP10990
http://www.kannapedia.net/strains/RSP10991
http://www.kannapedia.net/strains/RSP10995
http://www.kannapedia.net/strains/RSP10996
http://www.kannapedia.net/strains/RSP10997
http://www.kannapedia.net/strains/RSP10998
http://www.kannapedia.net/strains/RSP10999
http://www.kannapedia.net/strains/RSP11000
http://www.kannapedia.net/strains/RSP11002
http://www.kannapedia.net/strains/RSP11003
http://www.kannapedia.net/strains/RSP11005
http://www.kannapedia.net/strains/RSP11006
http://www.kannapedia.net/strains/RSP11007
http://www.kannapedia.net/strains/RSP11008
http://www.kannapedia.net/strains/RSP11009
http://www.kannapedia.net/strains/RSP11010
http://www.kannapedia.net/strains/RSP11011
http://www.kannapedia.net/strains/RSP11012
http://www.kannapedia.net/strains/RSP11013
http://www.kannapedia.net/strains/RSP11014
http://www.kannapedia.net/strains/RSP11028
http://www.kannapedia.net/strains/RSP11029
http://www.kannapedia.net/strains/RSP11030
http://www.kannapedia.net/strains/RSP11035
http://www.kannapedia.net/strains/RSP11041
http://www.kannapedia.net/strains/RSP11042
http://www.kannapedia.net/strains/RSP11043
http://www.kannapedia.net/strains/RSP11044
http://www.kannapedia.net/strains/RSP11046
http://www.kannapedia.net/strains/RSP11051
http://www.kannapedia.net/strains/RSP11052
http://www.kannapedia.net/strains/RSP11053
http://www.kannapedia.net/strains/RSP11054
http://www.kannapedia.net/strains/RSP11055
http://www.kannapedia.net/strains/RSP11056
http://www.kannapedia.net/strains/RSP11057
http://www.kannapedia.net/strains/RSP11058
http://www.kannapedia.net/strains/RSP11059
http://www.kannapedia.net/strains/RSP11060
http://www.kannapedia.net/strains/RSP11061
http://www.kannapedia.net/strains/RSP11062
http://www.kannapedia.net/strains/RSP11063
We are going to be accepting our first DASH payment for this at Medicinal Genomics.
An additional 80 strains were notarized on DASH this month.
The list should be in the DASHWatch report that will post shortly.
We also have two large grows from 2 different countries agree to sponsor.
Once payments are complete, we’ll announce who the additional sponsors are.
An additional 13 speakers have been selected and notified. We should have their names on the CannMed website shortly.
This is going to be a great event and showcasing this genome at the event will bring a lot of additional awareness to DASH.
This is my third time submitting it so clearly I need to hone my elevator pitch a bit more.
We reduced the scope and budget multiple times to make this very efficient use of capital.
Hoping to the Broad/MIT presentation I gave last week live before the vote.
https://www.dash.org/forum/threads/pre-proposal-make-dash-a-household-name-in-three-different-20b-industries.37708/#post-187922
https://www.freedomsphoenix.com/Media/Media-Files/001-0522110731-2018-05-22-Hours-1-3+-Kevin-McKernan---MedicalGenomicsCOM---Mindy-Patterson---TheCavalryGroupCOM.mp3
Should have a video of our Broad Institute MIT and Harvard presentation next week.
Presentation went well and a swarm of younger scientists peppered me with questions about revamping peer review.
In addition to this, we are demonstrating a way for Scientific publishing to be notarized on DASH. Consider all of the DASH investment in various alternative and truth based media. This may help to make DASH synonymous with unbiased truth. However, having truth in media is worthless if the scientific publishing mechanisms they defer to are corrupted as the media usually defers to the scientistic record. This peer review process is currently broken, poorly incentivized and having a replication crisis. Strike the root and get the scientific publishing on DASH. This will amplify the impact of the media channels on DASH as it will be a truth chain for financial information and also a truth chain for the scientific record. There are multiple other Large DASH investments that benefit from this relatively inexpensive investment (Alt36, Truth in Media etc).
Bringing even a small percentage of those industries to Dash would be an enormous benefit in terms of ROI. The project does not ask terribly much, but potentially provides enormous economic benefit, and that's not even getting in to the philanthropic aspect of all of this. I urge you to reconsider your assessment.
The proposal is indeed more focused on getting more DASH awareness and potential transaction volume in multiple different markets.
For a digital cash to succeed in the cannabis trade, we need better standards so customers can verify what is being sold.
Cannabis is hypervariable and Customer know this.
A reference genome builds the standards by which we fingerprint strains to provide biological barcodes for products in the industry.
This is analogous to forming a consensus on what the blocksize should be. Without this reference we can’t agree on what the product is and digital trade becomes compromised.
If DASH wants to become a trust worthy monetary solution in this market it needs marketing to build its name and reputation in the space. There is no better way to build credibility in the space than by constructing the reference genome of the plant and to cement DASHs name as the arbiter of scientific truth in the field.
The future of cannabis seed to sale tracking systems will be DNA fingerprint based. If this is a DASH derived reference genome, there is a higher likelihood of adoption of DASH as the monetary platform.
This white-paper may help to describe the importance of this for the field.
https://www.medicinalgenomics.com/blockchained-cannabis-dna/
https://medicinalgenomics.wistia.com/medias/clhm384o9y
solarguy
Plus, protecting everyone on earth from greedy companies who want to own a natural plant, that's insane! I hope you can prove that almost none of their plant is uniquely changed from previous cannabis plants. The world has no sense anymore.
Aside from that, from Dash's point of view, being used to register REAL innovation, at minimal cost, really almost free, taking the advantage away from those who own the system, would be something Dash could be proud of!
A big yes from me!